[PDF] Trans-ancestry epigenome-wide association meta-analysis of DNA methylation with lifetime cannabis use | Semantic Scholar (2024)

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@article{Fang2022TransancestryEA, title={Trans-ancestry epigenome-wide association meta-analysis of DNA methylation with lifetime cannabis use}, author={Fang Fang and Bryan C. Quach and Kaitlyn G. Lawrence and Jenny van Dongen and Jesse A. Marks and Sara Lundgren and Mingkuan Lin and Veronika V. Odintsova and Ricardo Costeira and Zongli Xu and Linran Zhou and Meisha Mandal and Yujing Xia and Jacqueline M. Vink and Laura Jean Bierut and Miina Ollikainen and Jack A. Taylor and Jordana T. Bell and Jaakko Kaprio and Dorret I. Boomsma and Ke Xu and Dale R. Sandler and Dana B. Hanco*ck and Eric O Johnson}, journal={Molecular Psychiatry}, year={2022}, volume={29}, pages={124 - 133}, url={https://api.semanticscholar.org/CorpusID:264779148}}
  • Fang Fang, Bryan C. Quach, Eric O Johnson
  • Published in medRxiv 31 December 2022
  • Medicine

The EWAS findings unravel the DNA methylation changes associated with lifetime cannabis use that are independent of cigarette smoking and may serve as a starting point for further research on the mechanisms through which cannabis exposure impacts health outcomes.

91 References

Epigenome-wide analysis uncovers a blood-based DNA methylation biomarker of lifetime cannabis use
    Christina A MarkunasD. Hanco*ck Jack A. Taylor

    Medicine, Biology


  • 2019

The EWAS findings provide evidence that blood-based DNAm is associated with lifetime cannabis use, and developed a multi-CpG classifier of lifetime Cannabis use using penalized regression of top EWAS CpGs.

  • 7
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Epigenome-wide association meta-analysis of DNA methylation with coffee and tea consumption
    Irma KarabegovićE. Portilla-Fernández M. Ghanbari

    Medicine, Environmental Science

    Nature Communications

  • 2021

A large EWAS on coffee and tea consumption in cohorts of European and African-American ancestries is presented, finding that coffee consumption is associated with differential DNA methylation levels at multiple CpGs, indicating that coffee-associated changes in DNAmethylation levels may explain the mechanism of action of coffee consumption in conferring risk of diseases.

  • 29
  • PDF
Genome-wide DNA methylation analysis of heavy cannabis exposure in a New Zealand longitudinal cohort
    Amy J. OsborneJohn F. Pearson Martin A. Kennedy



  • 2019

The effects of cannabis use on the mature human blood methylome differ from, and are less pronounced than, the effects of tobacco use, and that larger sample sizes are required to investigate this further.

  • 23
  • PDF
Epigenetic Signatures of Cigarette Smoking
    R. JoehanesA. Just S. London

    Medicine, Environmental Science

    Circulation. Cardiovascular genetics

  • 2016

Cigarette smoking has a broad impact on genome-wide methylation that, at many loci, persists many years aftersmoking cessation, indicating a pattern of persistent altered methylation, with attenuation, after smoking cessation.

  • 634
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Novel DNA methylation signatures of tobacco smoking with trans-ethnic effects
    C. ChristiansenJ. Castillo-Fernandez J. Bell

    Medicine, Biology

    Clinical epigenetics

  • 2021

Novel smoking-associated signals on the EPIC array are identified as possible biomarkers of exposure to smoking and may help improve the understanding of smoking-related disease risk.

  • 44
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Genome-wide DNA methylation association study of recent and cumulative marijuana use in middle aged adults
    D. NanniniYinan Zheng L. Hou


    Molecular Psychiatry

  • 2023

Several methylation markers, pathways, and diseases associated with recent and cumulative marijuana use in middle-aged adults are identified, providing additional insight into the association between marijuana use and the epigenome.

  • 3
  • PDF
DNA methylation signatures of aggression and closely related constructs: A meta-analysis of epigenome-wide studies across the lifespan
    J. van DongenF. Hagenbeek D. Boomsma

    Biology, Psychology


  • 2020

These findings point at loci that are sensitive to chemical exposures with potential implications for neuronal functions and it is hoped these results will be a starting point for studies leading to applications as peripheral biomarkers and to reveal causal relationships with aggression and related traits.

  • 19
  • PDF
Epigenome-wide association study of alcohol consumption in N = 8161 individuals and relevance to alcohol use disorder pathophysiology: identification of the cystine/glutamate transporter SLC7A11 as a top target
    Falk W. LohoffToni‐Kim Clarke K. Evans

    Medicine, Biology

    Molecular Psychiatry

  • 2021

The largest single-cohort epigenome-wide association study of alcohol consumption to date and cross-validated findings in AUD populations with relevant endophenotypes, as well as alcohol-related animal models suggest a strong role of abnormal glutamate signaling mediated by methylomic variation in SLC7A11.

  • 14
  • PDF
An epigenome-wide association study meta-analysis of educational attainment
    R. LinnérR. Linnér D. Benjamin

    Biology, Environmental Science

    Molecular Psychiatry

  • 2017

Evidence is provided on the associations between epigenetic modifications—in this case, CpG methylation—and educational attainment (EA), a biologically distal environmental factor that is arguably among the most important life-shaping experiences for individuals.

  • 64
  • PDF
GWAS of lifetime cannabis use reveals new risk loci, genetic overlap with psychiatric traits, and a causal effect of schizophrenia liability
    Joëlle A. PasmanK. Verweij J. Vink

    Medicine, Psychology

    Nature Neuroscience

  • 2018

A GWAS of lifetime cannabis use reveals new risk loci, shows that cannabis use has genetic overlap with smoking and alcohol use, and indicates that the likelihood of initiating cannabis use is causally influenced by schizophrenia.

  • 363
  • PDF



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    [PDF] Trans-ancestry epigenome-wide association meta-analysis of DNA methylation with lifetime cannabis use | Semantic Scholar (2024)


    How accurate is DNA methylation for age? ›

    Here, we present GP-age, an epigenetic non-linear cohort-based clock for blood, based upon 11,910 methylomes. Using 30 CpG sites alone, GP-age outperforms state-of-the-art models, with a median accuracy of ∼2 years on held-out blood samples, for both array and sequencing-based data.

    Does DNA methylation increase aging? ›

    Aging is often marked by the establishment of global hypomethylation and regions of CpG island hypermethylation. These changes in the epigenetic landscape may contribute to aging by adversely affecting genomic stability and gene regulation.

    How to do DNA methylation analysis? ›

    Currently, there are three primary methods to identify and quantify DNA methylation. These are: sodium bisulfite conversion and sequencing, differential enzymatic cleavage of DNA, and affinity capture of methylated DNA (1). Restriction enzyme based differential cleavage of methylated DNA is locus-specific.

    What is DNA methylation Google Scholar? ›

    DNA methylation is a heritable epigenetic mark involving the covalent transfer of a methyl group to the C-5 position of the cytosine ring of DNA by DNA methyltransferases (DNMTs).

    What are the negative effects of DNA methylation? ›

    DNA methylation, a process of adding a methyl group to DNA done by a DNA methyltransferase is a heritable (epigenetic) alteration leading to cancer, atherosclerosis, nervous disorders (Imprinting disorders), and cardiovascular diseases.

    What can DNA methylation tell us? ›

    DNA methylation also plays an important role in X-chromosome inactivation, genomic imprinting and silencing of transposable elements. DNA methylation data are important for understanding the mechanisms underlying these cellular and molecular events.

    Can DNA methylation cause disease? ›

    DNA methylation plays a role in many rheumatic diseases, such as systemic lupus erythematosus, systemic sclerosis, osteoarthritis, rheumatoid arthritis, dermatomyositis, and hypermobility syndromes.

    How does DNA methylation affect memory? ›

    DNMT3A2 protein catalyzes de novo DNA methylations. These several mechanisms convert external experiences into DNA methylations and initiated demethylations of neuronal DNA cytosines, causing changes in gene expression that are the basis of long-term memories.

    Can epigenetics reverse aging? ›

    Specifically, epigenetic reprogramming appears to be the most promising intervention at the moment, not only allowing it to slow down but also potentially reverse cellular ageing.

    Is a DNA methylation test worth it? ›

    Genetic methylation tests can help to identify your risk for serious health conditions, including cancer, cardiovascular disease, and neurodegenerative disorders, Paulvin explains.

    What is the best DNA methylation test? ›

    Bisulfite Sequencing. The technique of bisulfite sequencing is considered to be the “gold standard” method in DNA methylation studies.

    How much does a DNA methylation test cost? ›

    Methylation Analysis Pricing
    Number of samples14
    Cost per sample600227
    5 Primer Sets6901050
    Cost per sample690262
    6 Primer Sets7801200
    8 more rows

    Can DNA methylation be reversed? ›

    S.R. and S.K.B.

    Which enzyme is responsible for DNA methylation? ›

    DNA methylation is processed by a family of enzymes, the DNA methyl transferases (DNMTs), which are divided in three classes: DNMT1, DNMT2, and the DNMT3A/3B/3L.

    Does methylation damage DNA? ›

    DNA methylation is a reversible epigenetic mark, which has been implicated in DNA damage signaling, repair and replication. Sites of DNA methylation can trigger mutations, which are drivers of human diseases including cancer.

    How accurate is DNA testing for age? ›

    "The blood test, for example, has an accuracy of about 3.75 years over a whole age population, meaning that from newborns up to about 91 years of age our accuracy was about 3.75," said Bekaert. "The younger the individual is the higher the accuracy is because it has had less influence of the environment.

    What is the DNA methylation age predictor? ›

    At present, DNA methylation is the most promising biological biomarker applied for age assessment. The human genome contains around 28 million DNA methylation sites, many of which change with age. Several epigenetic clocks accurately predict chronological age using methylation levels at age associated GpG-sites.

    What is the DNA methylation clock for aging? ›

    DNA methylation clocks, novel biomarkers of aging, are composed of a group of cytosine-phosphate-guanine dinucleotides, the DNA methylation status of which can be used to accurately measure subjective age. These clocks are considered accurate biomarkers of chronological age for humans and other vertebrates.

    What is the role of DNA methylation in human age prediction? ›

    DNA methylation (DNAm) is a well-known factor signifying change during the aging process but also necessary for the development of mammals. Several studies reported that DNAm can be used as an important marker in predicting the age of a human.

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